3319-3322
| C-Terminal Modifications of Histidyl-N-benzylglycinamides To Give Improved Inhibition of Ras Farnesyltransferase, Cellular Activity, and Anticancer Activity in Mice
Dennis J. McNamara,
Ellen Dobrusin,
Daniele M. Leonard,
Kevon R. Shuler,
James S. Kaltenbronn,
John Quin III,
Scott Bur,
Charles E. Thomas,
Annette M. Doherty,
Jeffrey D. Scholten,
Karen K. Zimmerman,
Barbara S. Gibbs,
Richard C. Gowan,
Michael P. Latash,
Wilbur R. Leopold,
Sally A. Przybranowski, and
Judith S. Sebolt-Leopold
[Full Article -
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3323-3331
| Probing the Mechanism of Action and Decomposition of Amino Acid Phosphomonoester Amidates of Antiviral Nucleoside Prodrugs
Edward J. McIntee,
Rory P. Remmel,
Raymond F. Schinazi,
Timothy W. Abraham, and
Carston R. Wagner
[Full Article -
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3332-3335
| Synthesis of a Novel Sialic Acid Derivative (Sialylphospholipid) as an Antirotaviral Agent
Mamoru Koketsu,
Teruhiko Nitoda,
Hidetoshi Sugino,
Lekh R. Juneja,
Mujo Kim,
Takehiko Yamamoto,
Naoji Abe,
Tetsuya Kajimoto, and
Chi-Huey Wong
[Full Article -
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3336-3345
| Effect of a Chemical Modification on the Hydrated Adenosine Intermediate Produced by Adenosine Deaminase and a Model Reaction for a Potential Mechanism of Action of 5-Aminoimidazole Ribonucleotide Carboxylase
Michael P. Groziak,
Zhen-Wei Huan,
Hong Ding,
Zhaoyang Meng,
William C. Stevens, and
Paul D. Robinson
[Full Article -
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3346-3352
| Search for DNA Repair Inhibitors: Selective Binding of Nucleic Bases-Acridine Conjugates to a DNA Duplex Containing an Abasic Site
Nathalie Berthet,
Jean-François Constant,
Martine Demeunynck,
Pierre Michon, and
Jean Lhomme
[Full Article -
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3353-3358
| Synthesis of Gonadotropin-Releasing Hormone III Analogs. Structure-Antitumor Activity Relationships
Imre Mezö,
Sándor Lovas,
István Pályi,
Borbála Vincze,
Adrien Kálnay,
Gizella Turi,
Zsolt Vadász,
János Seprödi,
Miklós Idei,
Géza Tóth,
Éva Gulyás,
Ferenc Ötvös,
Mariann Mák,
Judit E. Horváth,
István Teplán, and
Richard F. Murphy
[Full Article -
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3359-3368
| Potent  4 1 Peptide Antagonists as Potential Anti-Inflammatory Agents
David Y. Jackson,
Clifford Quan,
Dean R. Artis,
Thomas Rawson,
Brent Blackburn,
Martin Struble,
Geraldine Fitzgerald,
Kathryn Chan,
Sheldon Mullins,
J. P. Burnier,
Wayne J. Fairbrother,
Kevin Clark,
Maureen Berisini,
Henry Chui,
Mark Renz,
Susan Jones, and
Sherman Fong
[Full Article -
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3369-3380
| Phenylimidazolidin-2-one Derivatives as Selective 5-HT3 Receptor Antagonists and Refinement of the Pharmacophore Model for 5-HT3 Receptor Binding
Franco Heidempergher,
Antonio Pillan,
Vittorio Pinciroli,
Fabrizio Vaghi,
Claudio Arrigoni,
Giorgio Bolis,
Carla Caccia,
Luciano Dho,
Robert McArthur, and
Mario Varasi
[Full Article -
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3381-3392
| Structure-Activity Relationships of (4-Acylpyrrol-2-yl)alkanoic Acids as Inhibitors of the Cytosolic Phospholipase A2: Variation of the Substituents in Positions 1, 3, and 5
Matthias Lehr
[Full Article -
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3393-3401
| New Orally Active Non-Peptide Fibrinogen Receptor (GpIIb-IIIa) Antagonists: Identification of Ethyl 3-[N-[4-[4-[Amino[(ethoxycarbonyl)imino]methyl]phenyl]- 1,3-thiazol-2-yl]-N-[1-[(ethoxycarbonyl)methyl]piperid-4-yl]amino]propionate (SR 121787) as a Potent and Long-Acting Antithrombotic Agent
Alain Badorc,
Marie-Françoise Bordes,
Paul de Cointet,
Pierre Savi,
André Bernat,
Alain Lalé,
Maurice Petitou,
Jean-Pierre Maffrand, and
Jean-Marc Herbert
[Full Article -
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3402-3407
| Synthesis and Stereochemical Structure-Activity Relationships of 1,3-Dioxoperhydropyrido[1,2-c]pyrimidine Derivatives: Potent and Selective Cholecystokinin-A Receptor Antagonists
Mercedes Martín-Martínez,
José M. Bartolomé-Nebreda,
Isabel Gómez-Monterrey,
Rosario González-Muñiz,
M. Teresa García-López,
Santiago Ballaz,
Ana Barber,
Ana Fortuño,
Joaquín Del Río, and
Rosario Herranz
[Full Article -
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3408-3422
| Anionic- and Lipophilic-Mediated Surface Binding Inhibitors of Human Leukocyte Elastase
John Regan,
Daniel McGarry,
Joseph Bruno,
Daniel Green,
Jack Newman,
Chin-Yi Hsu,
Jane Kline,
Jeffrey Barton,
Jeffrey Travis,
Yong Mi Choi,
Francis Volz,
Henry Pauls,
Richard Harrison,
Asher Zilberstein,
Shmuel A. Ben-Sasson, and
Michael Chang
[Full Article -
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3423-3433
| 7-Alkylidenecephalosporin Esters as Inhibitors of Human Leukocyte Elastase
John D. Buynak,
A. Srinivasa Rao,
George P. Ford,
Christa Carver,
Greg Adam,
Bolin Geng,
Brian Bachmann,
Samir Shobassy, and
Stephanie Lackey
[Full Article -
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3434-3441
| Cephalosporin 3'-Phloroglucide Esters and 7-(Phloroglucidamido)cephalosporins as Novel Antibacterial Agents
Jih Ru Hwu,
Ali A. Moshfegh,
Shwu-Chen Tsay,
Chun Chieh Lin,
Wen Nan Tseng,
Abdolmajid Azaripour,
Hasan Mottaghian, and
Gholam H. Hakimelahi
[Full Article -
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3442-3452
| Thromboxane Modulating Agents. 3. 1H-Imidazol-1-ylalkyl- and 3-Pyridinylalkyl-Substituted 3-[2-[(Arylsulfonyl)amino]ethyl]benzenepropanoic Acid Derivatives as Dual Thromboxane Synthase Inhibitor/Thromboxane Receptor Antagonists
Roger P. Dickinson,
Kevin N. Dack,
Clive J. Long, and
John Steele
[Full Article -
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3453-3455
| Protein Structure Determination Using A Combination of Comparative Modeling and NMR Spectroscopy. Application to the Response Regulator Protein, Spo0F
Brent L. Podlogar,
Gregory C. Leo,
Patricia A. McDonnell,
Deborah A. Loughney,
Gary W. Caldwell, and
John F. Barrett
[Full Article -
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3456-3465
| Syntheses and Biological Activities (Topoisomerase Inhibition and Antitumor and Antimicrobial Properties) of Rebeccamycin Analogues Bearing Modified Sugar Moieties and Substituted on the Imide Nitrogen with a Methyl Group
Fabrice Anizon,
Laure Belin,
Pascale Moreau,
Martine Sancelme,
Aline Voldoire,
Michelle Prudhomme,
Monique Ollier,
Danièle Sevère,
Jean-François Riou,
Christian Bailly,
Doriano Fabbro, and
Thomas Meyer
[Full Article -
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3466-3477
| 19-Nor-10-azasteroids, a New Class of Steroid 5-Reductase Inhibitors. 2. X-ray Structure, Molecular Modeling, Conformational Analysis of 19-Nor-10-azasteroids and Comparison with 4-Azasteroids and 6-Azasteroids
Antonio Guarna,
Ernesto G. Occhiato, and
Fabrizio Machetti
, Alessandro Marrucci,
Giovanna Danza, and
Mario Serio
, Paola Paoli
[Full Article -
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3478-3483
| Synthesis and Antiviral Activity of C2 Analogs of Enviroxime: An Exploration of the Role of Critical Functionality
Frantz Victor,
Richard Loncharich,
Joseph Tang, and
Wayne A. Spitzer
[Full Article -
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3484-3488
| Synthesis, Cardiotonic Activity, and Structure-Activity Relationships of 17-Guanylhydrazone Derivatives of 5-Androstane-3,14-diol Acting on the Na+,K+-ATPase Receptor
Alberto Cerri,
Fulvio Serra,
Patrizia Ferrari,
Elena Folpini,
Gloria Padoani, and
Piero Melloni
[Full Article -
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